Periodontal ligament stem cell: An update

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Periodontal Ligament Stem Cells

Millions of people experience consequential tooth loss related to irretrievable damage of the periodontium caused by deep caries, severe periodontal diseases or irreversible trauma, resulting in a decreased quality of life. Hence, dental scientists have focused much attention on tissue engineering techniques in an effort to address this condition. The periodontium is composed mainly of two soft...

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Allogeneic Periodontal Ligament Stem Cell Therapy for Periodontitis in Swine

Periodontitis is one of the most widespread infectious diseases in humans. It is the main cause of tooth loss and associated with a number of systemic diseases. Until now, there is no appropriate method for functional periodontal tissue regeneration. Here, we establish a novel approach of using allogeneic periodontal ligament stem cells (PDLSCs) sheet to curing periodontitis in a miniature pig ...

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Influence of nanotopography on periodontal ligament stem cell functions and cell sheet based periodontal regeneration

Periodontal regeneration is an important part of regenerative medicine, with great clinical significance; however, the effects of nanotopography on the functions of periodontal ligament (PDL) stem cells (PDLSCs) and on PDLSC sheet based periodontal regeneration have never been explored. Titania nanotubes (NTs) layered on titanium (Ti) provide a good platform to study this. In the current study,...

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The potential of human-derived periodontal ligament stem cells to osteogenic differentiation: An In vitro investigation

Background: Periodontal ligament stem cells (PDLSCs) are considered as a type of mesenchymal stem cell that is beneficial target for numerous clinical applications in periodontal tissue regeneration therapy. Materials and Methods: This study examined the effects of dexamethasone (Dex) on human PDLSCs in vitro. PDLSCs obtained from the roots of patient’s teeth were cultured with Dex (0....

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Periodontal Ligament Stem Cells - a Review

It is astonishing how quickly the field of genetics has progressed in the past 50 years since the structure of the DNA molecule was first reported. Another major discovery that may revolutionize health care practices has been the derivation of human embryonic stem cells. These cells can be coaxed into developing specific tissues or organs to replace ones that have been lost to disease. The iden...

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ژورنال

عنوان ژورنال: Journal of Advanced Clinical and Research Insights

سال: 2014

ISSN: 2393-8625

DOI: 10.15713/ins.jcri.30